Thermodynamics of Protein Folding and Aggregation

Friday, November 12, 2010: 8:30 AM
255 B Room (Salt Palace Convention Center)

Description:
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. The dynamics and aggregation mechanisms of intrinsically disordered proteins and peptides will also be of interest. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.


Sponsor:
Bioengineering


Chair:
Eva Chi
Email: evachi@unm.edu

Co-chairs:
Peter M. Tessier
Email: tessier@rpi.edu

Inchan Kwon
Email: ik4t@virginia.edu

Troy Cellmer
Email: cellmert@niddk.nih.gov



8:30 AM


8:50 AM
(750b) Structure-Activity Analysis of Small Molecules That Selectively Remodel Soluble Oligomers and Fibrils of Amyloid Aß
Ali Reza A. Ladiwala, Jason C. Lin, Shyam Sundhar Bale, J. Mauricio Mora-Pale, Jonathan S. Dordick and Peter M. Tessier




9:50 AM


10:00 AM
(750e) A Strategy for Designing a Molecular Probe for Detection of Beta-Amyloid Oligomers
Yang Hu, Baihao Su, Chung-sei Kim, Michael Hernandez, Jorge Ghiso and Jin Ryoun Kim


10:20 AM
(750f) Estimating Insulin Nuclei Concentration From Amyloid Fibrils: A Theoretical Approach
Mirco Sorci, Whitney Silkworth, Timothy Gehan and Georges Belfort


10:40 AM
(750g) Kinetics of Aggregation of Polyglutamine and Polyalanine Peptides
Joseph Bernacki, Robert H. Walters and Regina M. Murphy
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division