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Formation and Drug Release From Particles Produced Via Flash Nanoprecipitation

Wednesday, November 10, 2010: 1:10 PM
151 A/B Room (Salt Palace Convention Center)
Zhengxi Zhu1, Han Jing1, Adam Wohl2, Thomas Hoye2 and Christopher W. Macosko1, (1)Dept. of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, (2)Chemistry, University of Minnesota, Minneapolis, MN

Nanoparticles of highly insoluble drugs can be created by flash nanoprecipitation, FNP. Turbulent mixing combined with a polymer stabilizer can produce particles in the 100 nm size range, ideal for passive targeting of tumors and advantageous to increase solubility. We hypothesize that particles form by nucleation of ~10 nm which then aggregate rather than by nucleation and growth. We will report how particle structure controls drug release.

Extended Abstract: File Not Uploaded
See more of this Session: Nanomedicine and Drug Delivery II
See more of this Group/Topical: Topical F: Nanotechnology in Medicine