Functionalizable and Ultra Stable Nanoparticles Coated with Zwitterionic Poly(carboxybetaine) in Undiluted Blood Serum

Thursday, November 11, 2010: 4:00 PM
151 A/B Room (Salt Palace Convention Center)
Wei Yang and Shaoyi Jiang, Chemical Engineering, University of Washington, Seattle, WA

A new surface chemistry presenting an abundance of functional groups for ligand immobilization in an ultra-low fouling background all in one material for nanoparticles was introduced. This surface platform, as demonstrated by zwitterionic poly(carboxybetaine acrylamide) (polyCBAA) and carboxybetaine methacrylate (CBMA) coated nanoparticles, is not only ultra stable in undiluted human blood serum, but also can be conjugated to bio-molecules conveniently and effectively. Thus, this surface chemistry is ideal to create multi-functional nanoparticles for targeted delivery and diagnostics. In addition, this work clearly shows that 10% blood serum commonly used to evaluate the stability of nanoparticles is insufficient and a new evaluation criterion with undiluted blood serum is recommended.

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See more of this Session: Nanomaterials
See more of this Group/Topical: Topical F: Nanotechnology in Medicine