Session: Downstream Processing: Purification/Polishing (2009 Annual Meeting)

Thursday, November 12, 2009: 12:30 PM

Delta Ballroom B (Gaylord Opryland Hotel)

Description:

This session will focus on highlighting the latest advances in downstream processing relevant to purification/polishing operations including rapid process development, improved efficiency, cost reduction, integration of operations and handling of high titre streams. Topics to be covered include, but are not limited to: Uni- and multi-modal chromatography, membrane-based separations and filtration, extraction, precipitation and crystallization.

Sponsor:

Bioengineering

Co-Sponsor(s):

Pharmaceuticals (15b)

Chair:

Bruno F. Marques
Email: bruno.marques@gsk.com

Co-Chair:

Todd M. Przybycien
Email: todd@andrew.cmu.edu

12:30 PM

(556a) Knockout and Mutational Tailoring of Host Strains to Simplify Bioseparation
Patrick Bartlow, Ryan Haley, Mohammad Ataai and Robert R. Beitle

12:50 PM

(556b) Application of ATPS Strategies for the Potential Recovery of Recombinant Proteins From of Alfalfa Extracts
Celeste C. Ibarra-Herrera, Oscar Aguilar and Marco Rito-Palomares*

1:10 PM

(556c) Non-Chromatographic Antibody Purification Using Aqueous Two-Phase Systems
Lisong N. Mao, Matthew Westoby, Andy Koswara, Jameson Rogers, John Pieracci, Lynn Conley and Jörg Thömmes

1:30 PM

(556d) Optimization of ELP-Intein Mediated Protein Purification by Salt Substitution
Baley A. Fong, Wan-Yi Wu and David W. Wood

1:50 PM

Break

2:00 PM

(556e) Evaluation and Prediction of Protein Binding to Multi-Modal Anion Exchange Chromatographic Systems
Ying Hou and Steven M. Cramer

2:20 PM

(556f) Comparison of An Existing Scale-Down Membrane Adsorber Device to Ultra Small Membrane Adsorbers for Rapid Screening and Process Development
Brian Kluck, Tim Tully, Amit Mehta, Wolfgang Demmer, Rene Faber and Nathalie Fraud

2:40 PM

(556g) Knowledge-Driven Development: An Efficient Experimental Sequence for Refold Optimization
Sydney D. Hoeltzli, John J Buckley, Robert Gallavan and Gary V Johnson

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division