Solid Form Selection: Cocrystals, Salts, Solvates, and Polymorphs

Tuesday, November 10, 2009: 8:30 AM
Canal D (Gaylord Opryland Hotel)

Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.


Sponsor:
Crystallization and Evaporation


Chair:
Co-Chair:
Jan Sefcik
Email: jan.sefcik@strath.ac.uk


8:35 AM

9:00 AM
(224b) Accurate Lattice Energy Minimization of Cocrystals, Salts and Solvates Containing Flexible Molecules
Andrei V. Kazantsev, Panos G. Karamertzanis, Claire S. Adjiman and Constantinos C. Pantelides

9:50 AM
(224d) Alcohol Solvates of Sodium Naproxen
Krystle J. Chavez and Ronald W. Rousseau

10:15 AM
(224e) Challenges in the Solid State Characterization of a Non-Conventional Pharmaceutical Hydrate
Maria C. Sandoval, Roxana Schlam, George Crull, Qi Gao and Albert DelMonte
See more of this Group/Topical: Separations Division