Abstract: The Spectrin Network Influence Cell Mechanotransduction, Adhesion and Migration (2009 Annual Meeting)

Friday, November 13, 2009: 9:10 AM

Magnolia Boardroom B (Gaylord Opryland Hotel)

Zhixia Zhong, Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA

Katherine Wilson, Johns Hopkins University, Baltimore, MD

Kris Noel Dahl, Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA

The spectrin is widely expressed nucleated cell and located in both cytoplasm and nuclear membrane. We analyzed the influence of spectrin in cytoplasmic membrane via knockdown alpha II spectrin. The results show the focal adhesion and actin fibers become more oriented after konckdown alpha II spectrin. The alpha II spectrin-lacking cells under shear stress are more sensitive and shown spectial response to the shear force. Our results suggest that spectrin network is important in cell mechanotransduction, adhesion and migration

Extended Abstract: File Not Uploaded

See more of this Session: Cell Adhesion and Migration
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division