Thursday, November 20, 2008: 12:30 PM-3:00 PM
307-A (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#651 - Modeling in the Pharmaceutical Industry II (15B24)
The development of pharmaceuticals involves the development of both process and chemistry/formulation to produce the active pharmaceutical ingredient/final drug product. We invite contributions from industry and academia that address system-level process simulation (cycle time analysis, mass and energy balances, equipment usage, scheduling etc.) and/or more detailed unit operations modeling during process development and scale-up in pharmaceutical synthesis and formulation (e.g. reaction steps, kinetics, solvent chasing, crystallization, filtration, drying). Particular consideration will be given to examples of model development from laboratory data with model validation during scale-up and clear savings or greater process understanding as a result of process modeling.
Chair:Richard Schild
CoChair:Christopher L. Burcham
12:30 PMApplication of Quality by Design Principles In the Model Predictions for Scale-up of Tablet Film Coating
Andrew Prpich, Mary T. Am Ende, Thomas Katzschner, Veronica Lubczyk, Holger Weyhers, Georg Bernhard
12:50 PMUse of Molecular Modeling In the Formulation of Suspensions
Jamie T. Konkel, Allan S. Myerson
1:10 PMUse of Pharmacokinetic/pharmacodynamic (PK/PD) Modeling to Aid Formulation Selection
Larissa A. Wenning, Eseng Lai, Tami Crumley, Tian-Quan Cai, Fang Liu, M. G. Waters, Shaun Fitzpatrick, Julie Stone
1:30 PMComputer Aided Modelling in Pharmacokinetics as a Topical Issue
Michael Wulkow, Regina Telgmann
1:50 PMBreak
2:00 PMModeling of Tablet Dissolution Attendant to Tablet Microstructure Using a Multi-Process F-D Method
Dan Braido, Alberto Cuitino
2:20 PMFinite Element Analysis of Tablet Compaction Using a Modified Material Plasticity Model
Tuhin Sinha, Jennifer S. Curtis, Bruno C. Hancock, Carl R. Wassgren
2:40 PMModeling of the Compaction of Confined Powder Beds Using a Modified Quasi-Continuum Approach
Athanas A. Koynov, Alberto Cuitino

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