Monday, November 17, 2008: 12:30 PM-3:00 PM
Washington C Room (Loews Philadelphia Hotel)

Topical A: Systems Biology (TA)

#101 - Multiscale Systems Biology (TA005)
A fundamental goal of systems biology is to integrate different component parts of a biological system to understand the workings of the whole. Oftentimes the whole biological system will span either multiple time or spatial scales, if not both. The goal of this session is to discuss research that allows us to better understand such multiscale systems. Papers on both experimental and computational studies are welcome.
Chair:Ravi Radhakrishnan
CoChair:Yiannis Kaznessis
12:30 PMPredicting the Evolutionary Landscape of Multicellular Phenotypes
Anand R. Asthagiri
12:50 PMMultiscale Stochastic Dynamical Models Calibrated from AFM Single-Molecule Time Series and Computer Simulations
Christopher P. Calderon, Ching-Hwa Kiang, Dennis D. Cox, Nolan C. Harris, Wei-Hung Chen, Kuan-Jiuh Lin
1:10 PMLigand Specificity of C-Fos Expression Emerges from Spatiotemporal Control of Erbb Network Dynamics
Takashi Nakakuki, Marc R. Birtwistle, Yuko Saeki, Noriko Yumoto, Nagashima Takeshi, Babatunde A. Ogunnaike, Hatakeyama Mariko, Boris N. Kholodenko
1:30 PMSynthesis of Metabolic Pathways Using Thermodynamic Constraints and Parametric Sensitivity Analysis
Frank P. Marealle, Ye Wang, Jorge E. Gatica, María Rosa Hernández
1:50 PMBreak
2:00 PMHost and Viral Factors Control Stochastic Behavior In HIV-1 Gene Regulation and Latency
Kathryn Miller-Jensen, Ron Skupsky, John C. Burnett, Adam P. Arkin, David V Schaffer
2:20 PMStochastic Spatial and Non-Spatial Simulations of the Erbb Signaling Pathways Demonstrate the Importance of Spatial Organization In Signal Transduction
Michelle N. Costa, Dion Vlachos, Jeremy S. Edwards
2:40 PMReverse Engineering the Human Platelet
Jeremy E. Purvis, Manash S. Chatterjee, Lawrence F. Brass, Scott L. Diamond

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