Friday, November 21, 2008: 10:45 AM-1:15 PM
Room 104-A (Pennsylvania Convention Center)

Bioengineering (15c)

#756 - Bioseparations and Downstream Bioprocessing II (15C21)
Separation unit operations make up a critical portion of biologics downstream processes. Complexity inherently associated with biologics manufacture such as product heterogeneity and host impurities presents process challenges not typically encountered in small-molecule separations. With bioreactor titers increasing steadily over the last several years, production cost and operational pressures are shifting further to downstream. In addition, biological metabolites are still produced in relatively low amounts. The development of cost- and time-effective bioseparation and concentration unit ops is thus key to efficient downstream processes. This session will focus on highlighting the latest advances in bioseparations and downstream processing, aimed at cost reduction, improved efficiency, and shortend development time. Topics to be covered include, but are not limited to: Centrifugation; Crystallization, evaporation, and precipitation; Membrane-based separations; Adsorption and ion exchange; Extraction; Expanded-bed chromatography.
Chair:Bruno F. Marques
CoChair:Nihal Tugcu
CoSponsor(s):Pharmaceuticals (15b)
10:45 AM756aAnalysis of Different Affinity Membranes for the Primary Capture Step in Antibody Manufacturing
Cristiana Boi, Simone Dimartino, Giulio C. Sarti
11:05 AM756bPolymeric Immunoglobulin Receptor-D1 Based Affinity Ligand for Igm Purification
Satyen Gautam, Kai Chee Loh
11:25 AM756cA Rational Approach for the Design and Synthesis of Selective Displacers for the Chromatographic Purification of Proteins
Srinavya Vutukuru, Sandesh D. Kate, Scott A. McCallum, Christopher J. Morrison, Steven M. Cramer, Ravi S. Kane
11:45 AM756dA Non-Chromatographic Elp-Intein Based Protein Purification Technique: Application to Mammalian Expression System
Wan-Yi Wu, David Wood
12:05 PM Break
12:15 PM756eProgrammable Isoelectric Chromatofocusing and Its Application to Targeted Proteomics and Preparative Purification of Proteins
Derek Y.C. Choy, Charles Haynes
12:35 PM756fPost-Viral Inactivation Filtration for Impurity Removal in Biopharmaceutical Processes
Jeffrey E. Galvin, David Maheu, Sushil Abraham
12:55 PM756gSulphated Cellulose Membranes – An Economic Virus Capturing Method for Influenza Virus Purification
Lars Opitz, Nadine Solf, Udo Reichl, Michael W. Wolff

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