Monday, November 17, 2008: 12:30 PM-3:00 PM
Commonwealth A2 (Loews Philadelphia Hotel)

Pilot Plant Centenary Celebration (TF)

#77 - Challenges In Pharmaceutical Process Scale-up - Sponsored by Group 12b, Pilot Plants (TF002)
This session welcomes presentations on examples of challenges in pharmaceutical process scale-up with focus on pilot plant implementation. Pharmaceutical process areas include catalysis and reaction engineering, separations, crystallization and other unit operations for drug substance development, fermentation, chromatography and other unit operations for bioprocess development, granulation, blending, roller compaction and other unit operations for drug product development. Developments and advances in pilot plant operations and equipment to support pharmaceutical processing are of strong interest as well. Contributions from industry are particularly encouraged.
Chair:Robert Anthes
CoChair:Sanjeev Katti
CoSponsor(s):Pilot Plants (12b)
Pharmaceuticals (15b)
12:30 PM Welcoming Remarks
12:35 PM77aScale-up Challenges and Considerations In the Process Development of An Exothermic Reaction Step In Active Pharmaceutical Ingredient (API) Synthesis
Sanjeev Katti, Vitaly Nivorozhkin, Amy Baldwin
1:00 PM77bEffective Control of Residual Solvents In API Drying Using Fluid Bed Dryer
Yubo Yang, Ilaria Popolla, Melissa Kono
1:25 PM77cMinimizing Particle Agglomeration during Agitated Drying
William Bartels, Jose E. Tabora, John Wasylyk, Jessica Defreese, Prashant Deshpande
1:50 PM77dDevelopment of a Metals Removal Process for An Early Stage Active Pharmaceutical Ingredient (API) Process for Scale-up at the Pilot Plant Scale
Jason Hamm, Maxime Soumeillant, Susanne Kiau
2:15 PM77eAre High Throughput Technologies Useable for Engineering Scalability?
Robert Worth, Katarina Novakovic, Mark Willis, Allen R. Wright

See more of Topical F: Pilot Plant Centennial Celebration - Sponsored by Group 12b, Pilot Plants

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