Monday, November 17, 2008: 12:30 PM-3:00 PM
303-A (Pennsylvania Convention Center)

Bioengineering (15c)

#126 - Thermodynamics of Protein Folding and Aggregation (15C17)
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.
Chair:Todd M. Przybycien
CoChair:John A. Morgan
12:30 PMEarly Steps In Aggregation of Amyloidogenic Peptide Gnnqqny
Allam S. Reddy, Manan Chopra, Juan J. De Pablo
12:50 PMNew Twists to the Amyloid Folding Problem Revealed by Solid State NMR and Electron Microscopy of Alzheimer's Beta Amyloid Fibrils
Anant K. Paravastu, Isam Qahwash, Wa-Ming Yao, Richard D. Leapman, Steven C. Meredith, Robert Tycko
1:10 PMElucidating Therapeutic Monoclonal Antibody Aggregation
Veysel Kayser, Vladimir Voynov, Naresh Chennamsetty, Bernhard Helk, Kurt Forrer, Bernhardt L. Trout
1:30 PMAir/water Interface Induced Folding and Self-Assembly of Amyloid-Beta Peptide Seed Fibrillogenesis
Eva Y. Chi, Amy Winans, Shelli L Frey, Jaroslaw Majewski, Kristian Kjaer, Ka Yee C Lee
1:50 PMBreak
2:00 PMTransthyretin and Beta-Amyloid. A Regulatory Network In Protein Misfolding Disease?
Regina M. Murphy, Jiali Du
2:20 PMEffect of Fermentation Conditions on Inclusion Body Quality in High Cell Density E. Coli Fermentations
Rishard H. Chen, Clarissa S. Lui, Matthew P. DeLisa, Gerd Ritter, Lloyd J. Old, Carl Batt, Michael L. Shuler
2:40 PMTime Dependent Saxs Analysis of Insulin Oligomerization
Mirco Sorci, Joel E. Morgan, Kurt Erlacher, Georges Belfort

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