Tuesday, November 18, 2008: 8:30 AM-11:00 AM
Room 107-B (Pennsylvania Convention Center)

Bioengineering (15c)

#242 - Protein Engineering I: Therapeutics (15C14)
The ability to create proteins with desired properties is limited by our current understanding of the relationships between protein sequence, protein structure and protein function and by our current abilities to search sequence space in an efficient manner. This session seeks presentations on emerging topics and recent successes in both the understanding and engineering of protein form and function. Experimental and computational approaches that are of scientific, medical, and industrial significance are sought after. Possible areas of interest include, but are not limited to: computational design, directed evolution, protein mutations and modifications including non-natural amino acids, antibody or cytokine engineering, and protein medicinal chemistry.
Chair:George Georgiou
CoChair:Scott Banta
8:30 AMAffinity Maturation of Antibody Fragments Containing Non-Canonical Amino Acids
James A. Van Deventer, Tae Hyeon Yoo, David A. Tirrell
8:50 AMA Comparison of Antibodies Isolated from Immune Libraries by Two Different Anchored Periplasmic Expression (APEx) Systems
Thomas J. Van Blarcom, Sean Carroll, Yariv Mazor, George Georgiou
9:10 AMSynthetic Library Design Using the Fibronectin Domain as a Model System
Benjamin J. Hackel, K. Dane Wittrup
9:30 AMDeveloping Therapeutic Proteins by Engineering Ligand-Receptor Interactions
Douglas S. Jones, Stayce E. Beck, Stephen S. Lee, Jennifer R. Cochran
9:50 AMBreak
10:00 AMNovel Enzyme-Prodrug Therapy for Cancer
Roger G. Harrison, Yahya A. Lazrak, Luis F.F. Neves, Peter S. McFetridge, Arafat Tfayli
10:20 AMFabrication of Engineered Collagen-Like Biopolymers
Sam Wei Polly Chan, She-pin Hung, Richard Lathrop, Nancy A. Da Silva, Szu-Wen Wang
10:40 AMNon-Associating Heterodimeric DNA Methyltransferases as a Platform for Developing Site-Specific Methyltransferases
Glenna Meister, Srinivasan Chandrasegaran, Marc Ostermeier

See more of Food, Pharmaceutical & Bioengineering Division

See more of The 2008 Annual Meeting