Friday, November 21, 2008: 8:00 AM-10:30 AM
Room 104-A (Pennsylvania Convention Center)

Bioengineering (15c)

#726 - Bioseparations and Downstream Bioprocessing I (15C10)
Separation unit operations make up a critical portion of biologics downstream processes. Complexity inherently associated with biologics manufacture such as product heterogeneity and host impurities presents process challenges not typically encountered in small-molecule separations. With bioreactor titers increasing steadily over the last several years, production cost and operational pressures are shifting further to downstream. In addition, biological metabolites are still produced in relatively low amounts. The development of cost- and time-effective bioseparation and concentration unit ops is thus key to efficient downstream processes. This session will focus on highlighting the latest advances in bioseparations and downstream processing, aimed at cost reduction, improved efficiency, and shortend development time. Topics to be covered include, but are not limited to: Centrifugation; Crystallization, evaporation, and precipitation; Membrane-based separations; Adsorption and ion exchange; Extraction; Expanded-bed chromatography.
Chair:Sanjeev Katti
CoChair:Nihal Tugcu
CoSponsor(s):Pharmaceuticals (15b)
8:00 AM726aRecovery of Immunoglobulins from Bovine Serum through a Combination of Selective Precipitation and Crossflow Microfiltration
Georges Belfort, Adith Venkiteshwaran
8:20 AM726bUltra-Scale down Approaches for the Separation of Mammalian Cell Culture Broth In a Disc-Stack Centrifuge
Ferhana Zaman, Sa V. Ho
8:40 AM726cMonoclonal Antibody Primary Recovery Clarification: Evaluating Product Quality Impact, Process Optimization and Scale-up
Bryan C. Dravis, Michael D. Hilgert
9:00 AM726dDownstream Scale-up Evaluation for High-Titer Mammalian-Based Processes: Platform Strategies for Improved Clarification and Purification Throughput
Joshua Walker
9:20 AM Break
9:30 AM726eCapturing of Cell Culture Derived Vaccinia Virus by Membrane Adsorbers
Michael W. Wolff, Corina Sievers, Sylvia Lehmann, Lars Opitz, Sara Post-Hansen, Rene Djurup, Rene Faber, Udo Reichl
9:50 AM726fIntegrated IgG Fragmentation and Fragment Purification Using a Reactant Adsorptive Membrane Bioreactor Separator System
Deqiang Yu, Raja Ghosh

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