Wednesday, November 19, 2008: 12:30 PM-3:00 PM
Room 107-B (Pennsylvania Convention Center)

Bioengineering (15c)

#504 - Protein Structure, Function and Stability I (15C03)
We invite submissions in the areas of experimental, theoretical, and computational approaches to prediction, design, and/or optimization of protein structure, stability, and function. Studies may include structural analysis and engineering of proteins, creation or optimization of function, conformational analysis, analysis of thermal stability, mechanism of protein folding and misfolding, modes of protein degradation via physical and chemical routes, and other issues involving (over)expression, purification, and final biopharmaceutical product formulation. Reports of studies both in laboratory and processing settings relevant to all biotechnology products are welcome. Investigations of molecular pathways and mechanisms that provide insights into human diseases and potential treatments are of particular interest to this session.
Chair:Sheldon Park
CoChair:Peter M. Tessier
12:30 PMSynergetic Approach to Nonnative Aggregation by Multi-Assay Design of Experiments, Multivariate Statistics, and Mechanistic Kinetics
Yi Li, Babatunde A. Ogunnaike, Christopher J. Roberts
12:50 PMFolding and Aggregation of Polyglutamine Peptides and Proteins
Regina M. Murphy, Robert Walters, Matthew Tobelmann, Joseph Bernacki
1:10 PMSynthetic Prions Shed Light on Conformational Basis of Strain Diversity
David Colby, Stanley Prusiner
1:30 PMAnalysis of Protein Misfolding and Aggregation Using Peptide Microarrays
Moumita Bhattacharya, Jason Lin, Sumitra Sukumaran, Jonathan Dordick, Peter M. Tessier
1:50 PMBreak
2:00 PMComputational Predictions of the Enzymatic Activity of Single Deletion Mutants
Monica Berrondo, Jeffrey J. Gray
2:20 PMComputational Analysis and Design for Altered Cofactor Specificity
George A. Khoury, Hossein Z. Fazelinia, Costas D. Maranas
2:40 PMMolecular Design of Therapeutic Antibodies with Enhanced Stability
Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser, Bernhard Helk, Bernhardt L. Trout

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