Tuesday, November 18, 2008: 8:30 AM-11:00 AM
Room 106-B (Pennsylvania Convention Center)

Bioengineering (15c)

#194 - Advances In Cell Culture I (15C02)
Cell culture has advanced to a great extent with production of recombinant proteins in g/l quantities at 10,000 L scale and beyond becoming routine. In addition, developments such as the cell culture based flu vaccine promises more advances to come in the vaccine arena. Fundamental improvements in all steps from vector construction/transfection, cell line development, media development, bioreactor operation & process control, scale-up, etc have been key for these advances and studies in these areas are within scope and welcome for this session.
Chair:Shyamsundar Subramanian
CoChair:Ashraf Amanullah
8:30 AMIncreasing Productivity in Influenza Virus Production Virus Yields in High Cell Density Cultivations
Udo Reichl, Andreas Bock, Aljoscha Wahl, Jana Schwarzer
8:50 AMReducing Batch-to-Batch Variability of Agrobacterium-Mediated Transient Protein Expression in Plant Tissue Culture
Jeffrey S. Larsen, Wayne R. Curtis
9:10 AMIndependent Development of Hydrolysate-Containing and Hydrolysate-Free Cho Cell Culture Processes Yields Different Optimal Conditions
Diane M. Wuest, Polina Rapoport, Deborah Pascoe
9:30 AMDevelopment of An Animal Component-Free Cell Culture Process
Wen-Lin Tsai, Jennifer L. Autsen, Terrence Allotta, Judy H. Chou
9:50 AMIntermission
10:00 AMProteomics and Genome Sequencing to Enhance Chinese Hamster Ovary (CHO) Cell Productivity
Jeffrey C. Swanberg, Kelvin H. Lee
10:20 AMEffects of Cell Culture Conditions on Antibody N-Glycosylation - What Causes High Mannose 5 Glycoform
Efren Pacis, Feng Li, Darren Brown, Robert Bayer
10:40 AMConsistent Production of Immunoglycoproteins of Higher Adcc Activity by Controlling Fucosylation In Cho Cells
Vijay Yabannavar, Brian Albarran, Jackie McGourty, Richard Lowe

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