Thursday, November 20, 2008: 8:30 AM-11:00 AM
303-A (Pennsylvania Convention Center)

Engineering Fundamentals in Life Science (15d)

#587 - Disease Therapies and Diagnostics I (15D10)
Molecular and cellular science and engineering efforts over the past decade have given rise to numerous novel approaches for detecting and treating disease. These approaches have substantial potential for early detection and to provide highly specific and efficacious therapies for challenging disease targets (e.g. persistent pathogen infections, neurodegenerative disease and cancer). This session will highlight these creative approaches, including but not limited to biosensors, combination drug therapies, novel drug delivery systems (e.g. mechanisms to cross the blood-brain barrier), catalytic (e.g. proteolytic) therapies, nanotherapies, nucleic acid and RNA interference therapies, gene therapies, oncolytic viruses, cell and stem cell based therapies. Both discovery and development efforts, including therapeutic design approaches based on systems-level modeling, will be covered. Furthermore, translation of these ‘next generation’ therapeutics for the detection and treatment of specific disease targets will be emphasized.
Chair:Sundararajan V. Madihally
CoChair:Christa N. Hestekin
8:30 AMIn Vivo Monitoring of Viral Proteolytic Activity Using Luminescent Quantum Dot FRET-Based Probes
Divya Sivaraman, Marylynn V. Yates, Ashok Mulchandani, Wilfred Chen
8:50 AMFacile Size Isolation and Peptide Conjugation to Lipid-Coated Microbubbles: Application to Molecular Imaging of Renal Tumor Models
Mark A. Borden, Jessica Kandel, Darrell Yamashiro
9:10 AMEngineered Knottin Polypeptides. A New Class of In Vivo Molecular Imaging Agents
Richard H. Kimura, Aron M. Levin, Zhen Cheng, Sanjiv Sam Gambhir, Jennifer R. Cochran
9:30 AM“Aquaporin-1: Its Presence, Distribution and Quantification In Arterial Endothelium and How These Change with Chronic Hypertension – with Relevance to Early Atherogenesis”
Jimmy Deon Toussaint, Tieuvi Nguyen, Stewart Russell, Kung-Ming Jan, David Rumschitzki
9:50 AMBreak
10:00 AMQuartz Crystal Microbalance Analysis of Growth Kinetics for Aggregation Intermediates of the Amyloid-β Protein
Joseph A. Kotarek, Kathryn C. Johnson, Melissa A. Moss
10:20 AMEngineering of Embryonic Stem Cell Neurogenic Differentiation for Neurodegenerative Diseases
Daniel E. Kehoe, Ewa K. Stachowiak, Michal K. Stachowiak, Emmanuel (Manolis) S. Tzanakakis
10:40 AMOptimization of An Enrichment Process for Circulating Tumor Cells from the Blood of Head and Neck Cancer Patients through Depletion of Normal Cells
Liying Yang, James, Campbell Lang, Priya Balasubramanian, David Schuller, Amit Agrawal, Maciej Zborowski, Jeffrey J. Chalmers

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