Thursday, November 20, 2008: 3:15 PM-5:45 PM
307-B (Pennsylvania Convention Center)

Engineering Fundamentals in Life Science (15d)

#698 - Mathematical Approaches in Systems Biology (15D07)
This session is devoted to theoretical and computational studies of biological systems. Such systems include protein/DNA interactions, protein/protein interactions, genetic networks, metabolic pathways, and signal transduction pathways. Presentations will focus on theoretical and computational developments for the study of the behavior of these systems in response to stimulation or changes in their kinetic and thermodynamic properties. Contributions of novel computational strategies for systems biology are especially welcome.
Chair:Rajanikanth Vadigepalli
CoChair:Juergen Hahn
3:15 PMDe Novo Protein Design Based on Binding Affinity Predictions for the Discovery of Novel Inhibitors for Complement 3 and HIV-1
Meghan L. Bellows, Ho Ki Fung, Christodoulos A. Floudas
3:35 PMQuantitative Measurement Technique for Transcription Factor Profiles
Zuyi (Jacky) Huang, Fatih Senocak, Arul Jayaraman, Juergen Hahn
3:55 PMReconstructing Transcription Factor Networks Using the Living Cell Array
Eric Yang, Ioannis Androulakis, Martin Yarmush
4:15 PMSingle-Cell Behavior and Population Heterogeneity: An Inverse Modeling Approach for Computing the Intrinsic Physiological State Functions
Konstantinos Spetsieris, Nikos V. Mantzaris, Kyriacos Zygourakis
4:35 PMBreak
4:45 PMStochastic Simulation and Systems Analysis of Insulin-Stimulated GLUT4 Translocation
Eric C. Kwei, Kevin R. Sanft, Jason E. Shoemaker, Linda R. Petzold, Francis J. Doyle III
5:05 PMSmall World Network Models of Intercellular Coupling In the Mammalian Circadian Clock
Christina Vasalou, Mark Freeman, Erik D. Herzog, Michael A. Henson

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