Tuesday, November 18, 2008: 12:30 PM-3:00 PM
307-B (Pennsylvania Convention Center)

Engineering Fundamentals in Life Science (15d)

#300 - Metabolic Engineering for Tissues and Organs (15D05)
This session focuses on the development and application of metabolic engineering techniques and principles to mammalian systems, in the context of physiology and disease pathophysiology. Relevant topics include: (1) the characterization of pathway flux distributions in metabolic derangements of disease, such as diabetes, cancer, and hypercatabolic syndromes, etc.; (2) the development of nutritional, pharmacological, and other interventions to ameliorate these conditions; (3) the development of techniques to quantify fluxes in vivo, for example using mass balances, radiolabels, stable isotopes, etc.; (4) the development of techniques to elucidate the regulation of metabolic pathway networks using metabolomic, proteomic, and genomic information.
Chair:Francois Berthiaume
CoChair:Christina Chan
12:30 PMA Novel Control-Theoretic Approach for Modeling Metabolic Networks and Inferring Pathway Regulation
Jamey D. Young, Kristene L. Henne, John A. Morgan, Allan E. Konopka, Doraiswami Ramkrishna
12:50 PMModeling Glycolysis and Mitochondrial Metabolic Processes In Pancreatic β-Cells
Pradeep Nagaraja, Emmanuel (Manolis) S. Tzanakakis
1:10 PMUnraveling the Role of Central Metabolism In Hepatic Lipoapoptosis Using 13C Flux Analysis and Comprehensive Metabolic Profiling
Jamey D. Young, Yasushi Noguchi, Jose O. Aleman, Michael E. Hansen, Joanne K. Kelleher, Gregory Stephanopoulos
1:30 PMModulating the Lipoprotein-Dependent HCV Secretion
Yaakov Nahmias, Jonathan Goldwasser, Monica Casali, Raymond Chung, Martin Yarmush
1:50 PMBreak
2:00 PMEffects of Hormone and Amino Acid Supplementation In Optimal Liver Specific Functions of Hepatocytes
Hong Yang, Charles M. Roth, M.G. Ierapetritou
2:20 PMIn Vivo Metabolic Fluxes In Rat Livers: Effect of Burn Injury
Nripen S. Sharma, Maria-Louisa Izamis, Korkut Uygun, Francois Berthiaume, Martin Yarmush
2:40 PMEndothelial Cells Augment Hepatocytes Function In An Organotypical Model of Liver
Rohit Jindal, Yaakov Nahmias, Arno W. Tilles, Francois Berthiaume, Martin Yarmush

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