Monday, November 17, 2008: 8:30 AM-11:00 AM
401/402 (Marriott Philadelphia Downtown)

Engineering Fundamentals in Life Science (15d)

#41 - Intracellular Processes I (15D03)
The application of engineering principles to biological systems has promoted a quantitative understanding of cellular functions. This session seeks submissions that utilize either experimental methods or computational modeling to analyze intracellular processes in prokaryotes or eukaryotes. Areas of interest include, but are not limited to, binding and molecular interactions, signal transduction, intracellular trafficking, cytoskeletal dynamics, gene expression and function, and metabolism.
Chair:Dacheng Ren
CoChair:David Klinke
8:30 AMPropofol Induces a GABA-Independent Expression of C-Fos and Egr-1 In Neuronal Cells
Srivatsan Kidambi, Joel Yarmush, Wayne Fong, Sangeetha Kamath, Joseph SchianodiCola, Yaakov Nahmias
8:50 AMInfluence of Micrornas In the De-Differentiation of Primary Rat Hepatocyte Cells
Juan C. Lagos, Charles M. Roth
9:10 AMReduction of Adipocyte Triglyceride Accumulation through Targeted Perturbation of Pyruvate Metabolism
Hai Shi, Yaguang Si, Kyongbum Lee
9:30 AMA Computational Study of 'inside-out' Signal Dynamics and Integrin Activation during Leukocyte Trafficking
Michael Beste, Elena Lomakina, Richard E. Waugh, Daniel A. Hammer
9:50 AMBreak
10:00 AMAltered EGFR Trafficking and Signaling In Lung Cancers with Kinase-Inhibitor-Sensitizing Mutations
Matthew J. Lazzara, Douglas A. Lauffenburger
10:20 AMNicotinamide Increases the Megakaryocytic Maturation of Human Hematopoietic Stem Cells Primarily Due to Sirtuin Inhibition
Swapna Panuganti, Eleftherios T. Papoutsakis, William M. Miller
10:40 AMElasticity of Nsp1 and Its Binding with Kap95 Probed by Single Molecule Force Spectroscopy
Amit K. Dutta, Jacklyn Novatt, Tijana Jovanovic, Anna Sophia McKenney, Michael Rout, Brian T. Chait, Georges Belfort

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