Thursday, November 20, 2008: 12:30 PM-3:00 PM
Room 107-B (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#638 - Continuous Processing in the Chemical and Pharmaceutical Industry (15B23)
Continuous processing has long been applied successfully in all the chemical/material processing industries such as chemical, petroleum, food, plastics etc. Pharmaceutical manufacturing has been dominated by batch processing concept, where each unit dosage form is identified by a batch and tracked accordingly. Over the last decade, many successful efforts have been reported within pharmaceutical manufacturing involving continuous processing. While drug substance manufacturing has lead the way in implementing continuous processing, there is considerable effort being carried out in drug product manufacturing as well. This session invites research efforts and success stories implementing continuous processing for API and drug product manufacturing.
Chair:Mayur P. Lodaya
CoChair:Ecevit Bilgili
CoSponsor(s):Particle Production and Characterization (03a)
12:30 PMAspects of Screw Design for Wet Granulation Extrusion
Michael R. Thompson, Junfeng Sun
12:55 PMContinuous Production of Active Pharmaceutical Ingredients Using Recycle
Derek W. Griffin, Duncan A. Mellichamp, Michael F. Doherty
1:20 PMDevelopment of Continuous Processes for the Production of Pharmaceutical Substances Using Heterogeneous Catalysis
Heidrun Gruber-Woelfler, Rafael J. P. Eder, Birgit Wilding, Iris Pflueger, Peter Feenstra, Gerburg Schider, Alexander Muhr, Christoph Kutschera, Johannes G. Khinast
1:45 PMProcessing Pathway to Enhance Nanoparticle Stability
Varun Kumar, Robert K. Prud'homme
2:10 PMApplication of Data Reconciliation, Gross Error Detection and Real Time Optimization for Continuous Pharmaceutical Manufacturing
Michelle N. Chaffee, Gintaras V. Reklaitis, Venkat Venkatasubramanian
2:35 PMAnalysis of Operating Conditions of a Continuous Powder Mixer Using Pept
Patricia M. Portillo, Andy Ingram, Jonathan P.K. Seville, M.G. Ierapetritou, Fernando J. Muzzio

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