Friday, November 21, 2008: 8:00 AM-10:30 AM
Room 107-B (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#744 - Science and Engineering in Crystallization (15B15)
Robust crystallization of API with desired properties often requires a seamless interface between crystallization science and engineering principles. Crystallization science governs the chemical interactions that drive both nucleation and growth. Engineering principles provide the tools for scale-up and finesse the process. In this section, we invite authors to submit papers that apply both science and engineering to solve challenging scale-up problems, such as polymorph and enantiomer crystallization, particle size manipulation, and habit modification, to name a few.
Chair:Hector Guzman
CoChair:Monica H. Lamm
CoSponsor(s):Crystallization and Evaporation (02b)
8:00 AMLinear Models for Prediction of Ibuprofen Crystal Morphology Based on Hydrogen Bonding Propensities
Charles Acquah, Arunprakash T. Karunanithi, Matthew Cagnetta, Luke E. K. Achenie, Steven Suib
8:20 AMMechanism of the Formation of Enantiotropic Polymorphs in Solution Crystallization
Wenju Wu
8:40 AMPolymorph Selection In Solution Crystallization: Is Kinetics the Primary Determinant?
Sendhil K. Poornachary, Guangjun Han, Pui Shan Chow, Reginald B. H Tan
9:00 AMMechanistic Model for the Effect of Molecular Imposters on the Shape of Molecular Organic Crystals
Jacob P. Sizemore, M. F. Doherty
9:20 AMPrecise Tailoring of the Crystal Size Distribution by Optimal Seeding Time Profiles
Nicholas Kee, Xing Yi Woo, Reginald B. H Tan, Richard D. Braatz
9:40 AMDevelopment and Scale-up of a Seeded Acidic Co-Addition Crystallization
Adam S. Butterbaugh, Kevin D. Seibert, Paul C. Collins
10:00 AMSystematic Design of Supersaturation Controlled Crystallization Processes
Zoltan K. Nagy, Erum AAmir, Chris Rielly

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