Monday, November 17, 2008: 12:30 PM-3:00 PM
Room 113-A (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#68 - API Drug Formulation and Delivery (15B13)
This session will focus on the interaction between Active Pharmaceutical Ingredient (API) properties and formulation and delivery techniques required to achieve pharmaceutical benefit. We invite submissions on topics including but not limited to: API - excipient interactions, enhancement of API solubility, API surface, morphology or particle size effects, impact of API variability on its delivery, extended release delivery systems, processing strategies for property optimization.
Chair:Marylee Z. Southard
CoChair:Scott Shoemaker
12:30 PMEmulsion Function in a Simulated Gastric Environment. A Quantitative Study of Digestion Kinetics and Intestinal Permeability Enhancement
Fulden Buyukozturk, Hong Long, Rebecca L. Carrier
12:50 PMManufacturing of Biodegradable Drug-Polymer Nanocomposites for Controlled Drug Release by Supercritical Fluid Extraction of Emulsions
Johannes Kluge, Francesco Fusaro, Nathalie Casas, Marco Mazzotti, Ranjit Thakur, Gerhard Muhrer
1:10 PMProduction and Stabilization of Organic Crystalline Sub-Micron and Nanoparticles Using High Pressure Homogenization for Drug Delivery
Frank Romanski, M. Silvina Tomassone, Eric Jayjock, Fernando J. Muzzio
1:30 PMSurface Interactions and Microstructural Characterization of API Subjected to Cryogenic Milling
Diana Guzman, Dea Herrera-Ruiz, M. Teresa Carvajal
1:50 PMBreak
2:00 PMNovel Methods of Granule Structuring and Release Control
Frantisek Stepanek, Mansoor A. Ansari
2:20 PMPractical Methods for Improving Flow Properties of Active Pharmaceutical Ingredients
Kalyana Pingali, Kostas Saranteas, Fernando J. Muzzio
2:40 PMLimiting Flow Rate Analysis of Direct Compression Grade Hypromellose and Its Relationship to Powder Flowability
Karl Jacob, Kacee Ender, Dave Wallick, Harold Bernthal

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