Thursday, November 20, 2008: 3:15 PM-5:45 PM
Room 107-B (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#710 - PAT Implementation in Formulation Development (15B12)
The implementation of cutting edge analytical techniques (such as spectroscopy, and other in-situ methods) within pharmaceutical development is important in developing scientifically sound correlations between process conditions and quality product attributes. This session focuses on experimental and theoretical case studies in the areas of process analytical technology focusing on formulation design, process development, modeling of unit operations, scale-up, and advanced process control for parenteral and oral dosage forms.
Chair:Nancy E. Sever
CoChair:Padma J. Narayan
3:15 PMApplications of NIR In Blend Monitoring and beyond: Case Studies from Development
Nancy E. Sever
3:40 PMOptimization and Scale-up of High Shear Wet Granulation Processes Using Lasentec Fbrm and Pvm In-Situ Particle Characterization
Zane Arp, Benjamin Smith, Des O'Grady
4:05 PMCharacterizing In-Situ Particle Disintegration Mechanisms to Correlate Formulation Conditions to Tablet Dissolution Profiles
Des O'Grady, Eric Dycus, Eric J. Hukkanen, Jeff Seely
4:30 PMHigh Throughput Product / Process Monitoring and Control Using Automated Td-NMR Technology
Supriyo Ghosh
4:55 PMA Model-Based Framework for Systematic Product Quality Monitoring and Control
Ravendra Singh, Krist V. Gernaey, Rafiqul Gani
5:20 PMTowards a Robust, Greener API Process Via Cooling Crystallization
Evelina Kim, James Marek

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