Monday, November 17, 2008: 3:15 PM-5:45 PM
401/402 (Marriott Philadelphia Downtown)

Pharmaceuticals (15b)

#178 - Scale-up Issues in Pharmaceutical Formulation Development (15B10)
This session is devoted to the implementation of novel approaches taken to address challenging scale-up issues related to the pharmaceutical industry. Of particular interest would be the discussion of laboratory and pilot-scale work performed to define the critical aspects of the chemical synthesis and/or drug product manufacture and the corresponding approaches to their implementation at larger scales.
Chair:Michael B. Mackaplow
CoChair:Mayur P. Lodaya
3:15 PMThe Importance of Using Limiting Flow Rates to Assess the Flowability of Pharmaceuticals, Excipients and Their Mixtures
Karl Jacob, James K. Prescott
3:35 PMAn Investigation into the Effects of Binder Viscosity, Shear Rate, Mixing Time, and Primary Particle Size on the Spreading of a Liquid in a Particle Bed
Richard Turton, Tyler D. Simmons
3:55 PMCharacterization of Coating Formulation and Process Manufacturing Understanding as Tool for Determination of Coating's Strength
Giacomo Perfetti, G.M.H. Meesters, Willem J. Wildeboer, Chantal van der Meer
4:15 PMUse of Cfd to Identify and Resolve Cell Culture Issues Observed at Production Scale during Technology Transfer
Zhiwu Fang
4:35 PMBreak
4:45 PMModeling Hot-Melt Extrusion Pelletizers
Stefan Radl, Thomas Tritthart, Johannes G. Khinast
5:05 PMFormulation and Process Development of AtriplaŽ Tablets
Mark Menning
5:25 PMExpedite Development and Commercialization of Pharmaceuticals with Process Modeling and Scheduling Tools
Demetri Petrides, Charles Siletti

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