Wednesday, November 19, 2008: 8:30 AM-11:00 AM
Room 106-B (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#432 - New Approaches In Upstream Bioprocessing: Development and Manufacturing (15B09)
There are many challenges in the development of successful upstream processes. These include the development of processes that are amenable to scale-up, fundamental understanding of equipment design and operating parameters, as well as effective technology transfer. Compressed timelines pose additional challenges, necessitating efficient and coordinated process development. Topics such as the following are invited: Novel systems for process development Multi-product development using a standardized platform approach Significance and impact of upstream and downstream development on each other Approaches for scale-up/ technology transfer/ bioreactor design Use of models for scale-up / scale-down
Chair:Lori Herz
CoChair:Seshu Tyagarajan
8:30 AMA Scalable 30 Ml Bioreactor for Biopharmaceutical Screening
Mario M. Alvarez, David Bulnes-Abundis, Leydi Maribel Carrillo-Cocom, J. Manuel Aguilar-Yez, Keith Jhonson
8:50 AMA 24-Well Plate Microbioreactor Array for High-Throughput Cell Culture Process Development
Yuan Wen, Ning Liu, Xudong Zhang, Shang-Tian Yang
9:10 AMModeling the Platform: Leveraging Cross-Project Data to Understand Upstream Bioprocess Scale-up
Brian J. Stamper
9:30 AMEffect of Manufacturability Considerations In Facilitating Efficient Development and Transfer of An Escherichia Coli Process Producing Fc-Fusion Proteins
Henry Lin, Heideh Barkhordarian, Irene Liu, Jonathan Lull
9:50 AMBreak
10:00 AMProduction of Growth Hormone Receptor Antagonist In Nicotiana Tabacum Cells: Process Development, Optimization, Scale-up and Technology Transfer
Seshu Tyagarajan, Venkatesh Srinivasan
10:20 AMMammalian Cell Death Pathways Induced by Different Types of Shear Flow
Timm Tanzeglock, Miroslav Soos, Gregory N. Stephanopoulos, Massimo Morbidelli
10:40 AMModeling Shear-Induced Cho Cell Death In Rotary Lobe Pump
Hari Kamaraju, Kenneth Wetzel, William J. Kelly

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