Thursday, November 20, 2008: 3:15 PM-5:45 PM
303-B (Pennsylvania Convention Center)

Pharmaceuticals (15b)

#712 - Population Balance Modeling of Particulate Processes in the Pharmaceutical Industry (15B07)
This session invites papers in population balance applications to particulate processes particularly as applied in the pharmaceutical industry. Authors from industry and academia are encouraged to submit papers discussing such applications in the drug substance (API) processes(e.g. crystallization, nanoparticles) or in the drug product processes (e.g. granulation, milling or attrition) including population balance models development and experimental verification.
Chair:Pavol Rajniak
CoChair:Kumar M. Dhanasekharan
3:15 PM712aA Unified Approach to Mathematical Treatment of Multi-Particle Interactions during Size Reduction: Extending the Nonlinear Population Balance Model
Ecevit Bilgili, PhD
3:35 PM712bOn the Modeling of Milling In Pharmaceutical Industry
Nandkishor Nere, Ryan McCann, Kenneth Morris, Doraiswami Ramkrishna
3:55 PM712cNumerical Modeling of Two-Component Granulation
Themis Matsoukas, Carl L. Marshall Jr.
4:15 PM712dModelling and Simulation of the Crystallization of L-Glutamic Acid Polymorphs
Martin Hermanto, Nicholas Kee, Richard D. Braatz, Min-Sen Chiu
4:35 PM Break
4:45 PM712eBreakage of Needle-Shaped Particle Assemblies : Estimation of Breakage Functions from Discrete Element Simulations
Pavol Rajniak, David Lamberto, Zdenek Grof, Frantisek Stepanek
5:05 PM712fMultivariate Population Balance Equations for Functional Nanoparticle Formation Stabilized by Amphiphilic Block Copolymer Directed Assembly
Chungyin Cheng, R. Dennis Vigil, R. O. Fox
5:25 PM712gComponent Mixing In Bicomponent Aggregation: Classification of Kernels
Themis Matsoukas, Carl L. Marshall Jr., Kangtaek Lee, Taehoon Kim

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