Tuesday, November 18, 2008: 12:30 PM-3:00 PM
Room 109-B (Pennsylvania Convention Center)
Pharmaceuticals (15b)
#261 - Advances in API Process Development (15B02)
The application of PATs in process development laboratories has expedited development timelines, while providing increased process understanding. Traditional engineering approaches like kinetic regression and mass transfer analysis using PAT data and subsequent process simulation will be the focus of this session. Authors are encouraged to submit papers discussing novel techniques aimed at solving process problems and interesting API case studies.
Chair:	Partha Mudipalli
CoChair:	Jean W. Tom
12:30 PM	261a		Control of API Powder Properties Via Cake Washing Protocol and Agitated Drying Jessica L. Defreese, Derek Berglund, Prashant P. Deshpande, Mauricio Futran
12:50 PM	261b		Flocculated Amorphous Nanoparticles for Enhanced Bioavailability of Poorly-Water Soluble Drugs: In-Vitro and in-Vivo Studies Maria Andrea Miller, Michal E. Matteucci, Robert O. Williams III, Keith P. Johnston
1:20 PM	261c		Preserving API Hemihydrate during Vacuum Drying Erwin Irdam
1:40 PM	261d		Use of In-Line FTIR for the Kinetic Study of the Reaction and Degradation of Propylene Oxide In the Synthesis of a Pharmaceutical Intermediate Thomas Laporte, Zhongmin Xu, Fernando Quiroz, Lori Spangler, Chiajen Lai, Jean Tom
2:00 PM	261e		Control of Particle Sizes In An API Crystallization Process Via Thermal Cycling Yao-En (David) Li, Shaila Perez, Warrant Holmes, Yanhui Hu, Gerrie Liaw, Yubo Yang
2:20 PM	261f		Poly(Ethylene) Glycol-Drug Eutectic Compositions: Complex Morphologies and Crystallization Kinetics Phong Huynh, Paul Takhistov

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