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An Example from GSK 's Design for Manufacture Initiative: Use of Dynochem In Conjunction with Lab and Pilot Scale Data to Advance Process Understanding

Hawthorne Graddy, Robert Herrmann, Edward C. Webb, Ravinder Sudini, and Dharmesh Bhanushali. GlaxoSmithKline, King of Prussia, PA UW2820

Developed a mechanism to model the progress of the desired and un-desired reactions for a chemical transformation investigated within a parameter space at lab and pilot plant scale. This mechanism will be modeled in DynoChem using data collected from the lab and plant experiments. Preliminary evaluation of the data shows that desired reaction is equipment independent (50g to 40kg scale)