In this paper the sensitivity of different solubility models on the predicted CSD is evaluated for the cooling crystallization of acetaminophen in ethanol. Empirical, correlative thermodynamic, such as NRTL, and predictive thermodynamic models such as MOSCED are considered. Since crystallization is driven by supersaturation, the equilibrium solubility prediction of the solubility model will determine the predicted supersaturation profile. If the supersaturation profile is predicted incorrectly then the predicted CSD will also be incorrect. After the crystallization model's solubility sensitivity is evaluated, two methods are proposed and implemented to strengthen the crystallization model's prediction against solubility model errors.