We are using a two-pronged approach in the modeling of beta-amyloid. One model attempts to capture the basic physical features of beta-amyloid using a simple single-sphere side chain representation and an “HP” model description of the energetics of each side chain. The second model characterizes specific side chain interactions essential to the aggregation of beta-amyloid using either a one-or-two-sphere side chain representation and an “HP” + electrostatic interaction description of the energetics of each side chain. We explore how variations in the temperature, concentration, hydrophobic strength, and quench rate affect the formation and structure of beta-amyloid. Movies will be shown of the aggregation process.