In this work we present the development of heterogeneous catalysts and the investigation of their efficiency, long term stability and reusability. In a further step, these catalytic systems were implemented in continuous flow setups, which can be used for the production of pharmaceutical substances, such as
- preparation of amines by hydrosilylation of imines using heterogeneous Group 4 metallocenes
- application of heterogeneous Palladium-catalysts for the syntheses of arylpiperazines
- heterogeneous biocatalysis using enantioselective immobilized enzymes and
- particle formation using microfluidic devices
Preliminary results show that the developed setups lead to improved practicability and flexibility of the processes. Thus, these novel reaction systems constitute promising alternatives to existing batch applications.