A thermodynamic film coating model was used to determine the range of inlet air temperatures required to match the exhaust air conditions across the coaters at the target spray rates (600 – 1000 g/min) and pan air flow rate (6000 m3/hr). A film coating atomization model was used to determine the atomizing air pressure set point to achieve a mean coating solution droplet diameter of approximately 26 microns across the three coaters. Based on the model predictions, the following equipment set points were determined; (1) upper and lower inlet air temperatures of 75°C and 65°C, respectively, to maintain environmental similarity during film coating, and (2) atomization air pressure of 3.0 bar at the 600 g/min spray rate and 3.5 bar at the 1000 g/min spray rate to attain the desired droplet diameter. The recommendations were provided to the commercial site to guide the design of their scale-up trial runs. The results from the actual trials were compared against the corresponding model predictions to assess the validity of the guidance provided based on the two models. The results from this study illustrate how the thermodynamic and atomization film coating models can be used to improve the efficiency of the tablet film coating scale-up process.