Tuesday, November 6, 2007: 12:30 PM-3:00 PM
Room 250 A (Salt Palace Convention Center)

Bioengineering (15c)

#219 - Cell Culture for Cell Therapies (15C11)
This session will focus on issues related to the culture, differentiation, and proliferation of cells for use in cellular therapies. Cells and tissues of interest include embryonic stem cells, mesenchymal stem cells and adult progenitor cells such as skin, nerve, or liver progenitors, as well as primary cells such as pancreatic islets, hepatocytes, blood, skin, and nerve cells. Important issues include: (1) Regulation of stem/progenitor cell expansion and directed differentiation, (2) Development of culture media and control of the cellular microenvironment (PO2, pH, shear, and ECM), (3) Development of culture systems that mimic key aspects of the stem/progenitor cell niche, (4) Quality control and validation assays for cell characterization, (5) Development of bioreactors and microfluidics for automated differentiation or proliferation of cells, and (6) Improved recovery and purification of desired cell populations.
Chair:William M. Miller
CoChair:Yaakov Nahmias
12:30 PMStem Cell Self-Renewal In A Suspension Bioreactor Without Serum
Daniel E. Kehoe, Lye T. Lock, Manolis S. Tzanakakis
12:50 PMActivin Alters The Kinetics Of Endoderm Induction In Embryonic Stem Cells Cultured On Collagen Gels
Natesh Parashurama, Yaakov Nahmias, Cheul Cho, Daan Van Poll, Arno Tilles, Francois Berthiaume, Martin L. Yarmush
1:10 PMTuning Hydrogel Modulus And Ligand Density Independently To Control Adult Neural Stem Cell Self-Renewal And Differentiation
Krishanu Saha, Kevin E. Healy, David V. Schaffer
1:30 PMInterstitial Flow Modulates 3-D Human Mesenchymal Stem Cell Construct Development
Feng Zhao, Katelyn Sellgren, Teng Ma
1:50 PMIncreased Erk Activation and Intracellular Nadh Levels May Explain Nicotinamide-Mediated Increases in Megakaryocyte Size, Ploidy and Proplatelet Formation
Lisa M. Giammona, Eleftherios T. Papoutsakis, William M. Miller
2:10 PMCo-Culture Of 3T3-L1 Cells With Human Umbilical Vein Endothelial Cells
Ning Lai, Kyongbum Lee
2:30 PMOptimization Of The Generation Of Alloreactive Depleted T-Cell Transplants: The Challenge Of Nonspecific Binding
Ying Xiong, Xiaodong Tong, Sherif Farag, Maciej Zborowski, Jeffrey J. Chalmers

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