Wednesday, November 7, 2007: 8:30 AM-11:00 AM
Room 251 C (Salt Palace Convention Center)

Bioengineering (15c)

#386 - Thermodynamics of Protein Folding and Aggregation (15C08)
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.
Chair:Christopher J. Roberts
CoChair:Thomas M. Truskett
CoSponsor(s):Thermodynamics and Transport Properties (01a)
8:30 AMUltra-Fast Folding Of The Villin Subdomain: Nanosecond T-Jump Measurements In Denaturant
Troy Cellmer, William Eaton, Jim Hofrichter
8:50 AMIn Silico Protein Fragmentation Reveals The Importance Of Critical Nuclei In Domain Reassembly
Lydia M. Contreras, Ernesto Borrero-Quintana, Fernando A. Escobedo, Matthew P. DeLisa
9:10 AMQuaternary Self-Association of Gst-Tagged Viral Proteins
D. I. Lipin, Yap Pang Chuan, L. Lua, A. P. J. Middelberg
9:30 AMMemory and Reversibility of Insulin Oligomers
Mirco Sorci, Arpan Nayak, Chuang-Chung Lee, Gregory J. McRae, Robert Grassucci, Ingrid Hahn, Joachim Frank, Georges Belfort
9:50 AMIntermission
10:00 AMSubtle Defects In Transthyretin Quaternary Structure Prevent Its Inhibitory Action On Beta-Amyloid Aggregation
Regina M. Murphy, Lin Liu, Jie Hou
10:20 AMComputer Simulation Of Protein Aggregation Kinetics Using An Intermediate Resolution Model
Erin M. Phelps, Carol K. Hall
10:40 AMTowards Understanding Non-Integer Order Kinetics of Protein Denaturation
Jan Sefcik, Peter Grancic, Carl J. Schaschke

See more of Food, Pharmaceutical & Bioengineering Division

See more of The 2007 Annual Meeting