Wednesday, November 7, 2007: 8:30 AM-11:00 AM
Room 251 C (Salt Palace Convention Center)

Bioengineering (15c)

#386 - Thermodynamics of Protein Folding and Aggregation (15C08)
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.
Chair:Christopher J. Roberts
CoChair:Thomas M. Truskett
CoSponsor(s):Thermodynamics and Transport Properties (01a)
8:30 AM386aUltra-Fast Folding Of The Villin Subdomain: Nanosecond T-Jump Measurements In Denaturant
Troy Cellmer, William Eaton, Jim Hofrichter
8:50 AM386bIn Silico Protein Fragmentation Reveals The Importance Of Critical Nuclei In Domain Reassembly
Lydia M. Contreras, Ernesto Borrero-Quintana, Fernando A. Escobedo, Matthew P. DeLisa
9:10 AM386cQuaternary Self-Association of Gst-Tagged Viral Proteins
D. I. Lipin, Yap Pang Chuan, L. Lua, A. P. J. Middelberg
9:30 AM386dMemory and Reversibility of Insulin Oligomers
Mirco Sorci, Arpan Nayak, Chuang-Chung Lee, Gregory J. McRae, Robert Grassucci, Ingrid Hahn, Joachim Frank, Georges Belfort
9:50 AM Intermission
10:00 AM386eSubtle Defects In Transthyretin Quaternary Structure Prevent Its Inhibitory Action On Beta-Amyloid Aggregation
Regina M. Murphy, Lin Liu, Jie Hou
10:20 AM386fComputer Simulation Of Protein Aggregation Kinetics Using An Intermediate Resolution Model
Erin M. Phelps, Carol K. Hall
10:40 AM386gTowards Understanding Non-Integer Order Kinetics of Protein Denaturation
Jan Sefcik, Peter Grancic, Carl J. Schaschke

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