Monday, November 5, 2007: 8:30 AM-11:00 AM
Room 253 A (Salt Palace Convention Center)

Pharmaceuticals (15b)

#47 - Separations in Biopharmaceutical Process Development (15B13)
The design of separations operations is a key component of biopharmaceutical process development. This session will focus on topics including (but not limited to): novel separation methods, selection of process steps, filter/chromatography media selection, optimization of conditions and scale-up.
Chair:Chase Duclos-Orsello
CoChair:Marylee Z. Southard
8:30 AMOptimization of Primary and Secondary Clarification Using Failure Mode and Effect Analysis
Kara Fothergill, Willem Kools
8:50 AMCharacterization Of Downstream Processing Steps Used In The Purification Of A Monoclonal Antibody
Nihal Tugcu, Jonida Basha, M. Ellen Dahlgren, David J. Roush, Kent E. Goklen
9:10 AMApplication Of Process Analytical Technology Towards A Chromatography Step In A Biotech Process
Marcella Yu, Samuel Yeboah, Ashutosh Sharma, Anurag Rathore
9:30 AMModeling Of Vapor-Liquid Equilibrium To Design A Rectifying Column For The Isolation Of An Active Pharmaceutical Ingredient Intermediate From A Biotransformation Reaction
Mark Brower, Kent E. Göklen, Brendan Grau
9:50 AMBreak
10:00 AMEfficient Influenza Virus Capture From Cell Cultivation Broth By A Novel Affinity Chromatography
Lars Opitz, Anke Zimmermann, Sylvia Lehmann, Yvonne Genzel, Holger Lübben, Udo Reichl, Michael W. Wolff
10:20 AMScale-up of Constant Pressure Operations
Willem Kools, Jonathan Royce
10:40 AMCharacterization Of A Hybrid Particle-Nonwoven Membrane Separation Medium
M. Omon Herigstad, Patrick V. Gurgel, Ruben Carbonell

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