Monday, November 5, 2007: 8:30 AM-11:00 AM
Room 251 E (Salt Palace Convention Center)

Bioengineering (15c)

#10 - Advances in Protein Expression and Post-Translational Modification (15C03)
Increasing demand for recombinant proteins has focused research on techniques for improving protein expression and controlling post-translational processing. We invite papers on all aspects of protein expression including novel cell systems, expression vectors, and culture conditions. Submissions dealing with post-translational processing including glycosylation, editing and secretion are also invited. Papers may deal with any cell type including bacteria, yeast, mammalian, insect and plant cell cultures.
Chair:Eric T. Boder
CoChair:Matthew DeLisa
8:30 AMImproved Expression of Recombinant Protein Using a Cysteine Protease and Chitinase Deficient Bombyx Mori Multiple Nucleopolyhedrovirus Bacmid System in Silkworm Larvae
Masato Hiyoshi, Takahiro Abe, Tatsuya Kato, Enoch Y. Park
8:50 AMEffects Of Microcarrier Culture And Temperature Shift On Productivity And Glycosylation Of Recombinant Proteins Produced In Chinese Hamster Ovary Cells
Jong Hyun Nam, Fuming Zhang, Myriam Ermonval, Robert J. Linhardt, Susan Sharfstein
9:10 AMHeterologous Expression Of Fungal Polyketide Synthases
Suzanne M. Ma, Yi Tang
9:30 AMA Versatile Selection Technology For Intracellular Protein-Protein Interactions Mediated By A Unique Bacterial Hitchhiker Transport Mechanism
Dujduan Waraho, Matthew DeLisa
9:50 AMBreak
10:00 AMHigh-Throughput Cell-Based Screening for Therapeutic Antibody Process Development and An Investigation of the Biochemical Network for Specific Mab Productivity
Tiffany D. Rau, R. Robert Balcarcel
10:20 AMTranscriptional And Metabolic Responses In High-Cell Density Cultures During Temperature-Induced Synthesis Of Recombinant Protein In Escherichia Coli: A Scale-Down Study
Luis Caspeta, Noemí Flores, Francisco Bolívar, Octavio T. Ramírez
10:40 AMEffect Of Glycosylation On The Stability Of Transgenic Antibodies
Andrea Cascio, Daniel Forciniti

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