Thursday, November 8, 2007: 8:30 AM-11:00 AM
Room 250 E (Salt Palace Convention Center)

Engineering Fundamentals in Life Science (15e)

#557 - Receptor-Mediated Phenomena (15E07)
Receptor mediated phenomena are important mechanisms by which cells communicate with their environment. In this session, we are seeking papers which examine a variety of receptor mediated phenomena, associated with such processes as intracellular signaling, cell-cell signaling, mechanotransduction, or tissue remodeling for example. Of particular interest are studies involving apoptosis and differentiation. Modeling and experimental approaches to examining receptor mediated phenomena are welcome.
Chair:Michael R. King
CoChair:Ian J. Laurenzi
8:30 AMActivating Innate Immunity Through Toll-Like Receptors: Mechanism Of Signal Induction Is Elucidated By Quantifying Receptor-Ligand Complex Formation
Joshua N. Leonard, Janine Askins, Yan Wang, Rodolfo Ghirlando, Joseph Shiloach, Jessica K. Bell, David H. Margulies, David R. Davies, David M. Segal
8:50 AMNovel Flow Patterns Reveal A Localized Mechanoreceptor Of Fluid Shear Stress In Endothelial Cells
Cynthia Reinhart-King, Keigi Fujiwara
9:10 AMImproved Statistical Approach To Quantification Of Tether Bond Dynamics
Ian J. Laurenzi
9:30 AMDirect and Indirect Regulation of Growth Factor Binding and Signaling by Proteoglycan Binding Competitors
Kimberly Forsten-Williams, Chia Lin Chu, Jo Ann Buczek-Thomas, Matthew A. Nugent
9:50 AMBreak
10:00 AMUse Of Trail To Deliver An Apoptotic Signal To Rolling Cancer Cells Under Shear
Kuldeepsinh Rana, Nichola Charles, Jane L. Liesveld, Michael R. King
10:20 AMSignaling Crosstalk Between Soluble Factors And Cell-Cell Interactions
Nicholas A. Graham, Jin-Hong Kim, Melissa Pope, Anand R. Asthagiri
10:40 AMIdentifying Downstream Targets Of Cox-2 Which Regulate Extracellular Matrix Maintenance And Apoptosis In Shear-Induced Chondrocytic Cells
Joshua David Stull, Zachary Ryan Healy, Konstantinos Konstantopoulos

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