Monday, November 5, 2007: 12:30 PM-3:00 PM
Room 250 C (Salt Palace Convention Center)

Bioengineering (15c)

#104 - Protein Engineering: Therapeutics (15C02)
The ability to create proteins with desired properties is limited by our current understanding of the relationships between protein sequence, protein structure and protein function and by our current abilities to search sequence space in an efficient manner. This session seeks presentations on emerging topics and recent successes in both the understanding and engineering of protein form and function. Experimental and computational approaches that are of scientific, medical, and industrial significance are sought after. Possible areas of interest include, but are not limited to: computational design, directed evolution, protein mutations and modifications including non-natural amino acids, antibody or cytokine engineering, and protein medicinal chemistry.
Chair:Jennifer A. Maynard
CoChair:David W. Wood
12:30 PMWelcoming Remarks
12:50 PMEngineering Interleukin-2 For The Inhibition Of Regulatory T Cells
David V. Liu, K. Dane Wittrup
1:10 PMCell-Surface Display Of Antibody Fragments Containing Non-Canonical Amino Acids
James A. Van Deventer, Tae Hyeon Yoo, David A. Tirrell
1:30 PMA Comparison Of Novel Antibodies Isolated By Two Different Anchored Periplasmic Expression (Apex) Systems
Thomas J. Van Blarcom, George Georgiou
1:50 PMEngineering Transcription Factors with Novel DNA-Bind Specificity
Tasha Desai, Christopher V. Rao
2:10 PMBreak
2:20 PMTurning Ribosome Display Outside In For Intracellular Protein Engineering
Lydia M. Contreras, Matthew P. DeLisa
2:40 PMDirected Evolution of Structured Peptides
Karuppiah Chockalingam, Scott Banta
3:00 PMEngineering High-Affinity, Specific Peptide Ligands To Vascular Endothelial Growth Factor
Sophia A. Kenrick, Patrick Daugherty
3:20 PMConcluding Remarks

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