| Thursday, November 8, 2007: 8:30 AM-11:00 AM | |||
| Room 250 C (Salt Palace Convention Center) | |||
Engineering Fundamentals in Life Science (15e) | |||
| #530 - Design and Engineering of Novel Therapeutic Strategies (15E02) | |||
| Molecular and cellular science and engineering efforts over the past decade have given rise to numerous novel approaches for treating disease. These approaches have substantial potential to provide highly specific and efficacious therapies for challenging disease targets (e.g. persistent pathogen infections, neurodegenerative disease and cancer). This session will highlight these creative approaches, including but not limited to combination drug therapies, novel drug delivery systems (e.g. mechanisms to cross the blood-brain barrier), catalytic (e.g. proteolytic) therapies, nanotherapies, nucleic acid and RNA interference therapies, gene therapies, oncolytic viruses, cell and stem cell based therapies. Both discovery and development efforts, including therapeutic design approaches based on systems-level modeling, will be covered. Furthermore, translation of these ‘next generation’ therapeutics for the treatment of specific disease targets will be emphasized. | |||
| Chair: | James E. Henry | ||
| CoChair: | John P. Fisher | ||
| 8:30 AM | 530a | Promising Vaccine Adjuvants Based On Novel Amphiphilic Polyanhydrides Maria P. Torres, Jennifer Wilson, Michael Wannemuehler, Surya K. Mallapragada, Balaji Narasimhan | |
| 8:55 AM | 530b | Anti-HIV Rnai Targeting A Highly Conserved Viral Sequence Results In Novel Mechanisms Of Escape Priya S. Shah, Joshua N. Leonard, David V. Schaffer | |
| 9:20 AM | 530c | Quantitative Characterization Of Defective Interfering Virus-Like Particles Kristen Thompson, John Yin | |
| 9:45 AM | 530d | Targeted Gene Therapy of B-Cell Lymphoma by Engineered Retroviral Vectors Haiguang Yang, Leslie Bailey, Yuning Lei, Taehoon Cho, Kye Il Joo, Bingbing Dai, Lili Yang, Pin Wang | |
| 10:10 AM | 530e | Impact Of Target Mrna Structure On Sirna Silencing Efficiency And Immune Stimulation In RNA Interference Joseph A. Gredell, Angela Berger, S. Patrick Walton | |
| 10:35 AM | 530f | In Vitro Studies Of Selective Targeting Of Pigmented Retinal Pigment Epithelial (Rpe) Cells And Subsequent Bio-Stimulation Qing Song, Ramon Risco Delgado, Mark Latina, Francosi Berthiaume, Yaakov Nahmias, Martin Yarmush | |
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