Thursday, November 8, 2007: 8:30 AM-11:00 AM
Room 250 C (Salt Palace Convention Center)

Engineering Fundamentals in Life Science (15e)

#530 - Design and Engineering of Novel Therapeutic Strategies (15E02)
Molecular and cellular science and engineering efforts over the past decade have given rise to numerous novel approaches for treating disease. These approaches have substantial potential to provide highly specific and efficacious therapies for challenging disease targets (e.g. persistent pathogen infections, neurodegenerative disease and cancer). This session will highlight these creative approaches, including but not limited to combination drug therapies, novel drug delivery systems (e.g. mechanisms to cross the blood-brain barrier), catalytic (e.g. proteolytic) therapies, nanotherapies, nucleic acid and RNA interference therapies, gene therapies, oncolytic viruses, cell and stem cell based therapies. Both discovery and development efforts, including therapeutic design approaches based on systems-level modeling, will be covered. Furthermore, translation of these ‘next generation’ therapeutics for the treatment of specific disease targets will be emphasized.
Chair:James E. Henry
CoChair:John P. Fisher
8:30 AMPromising Vaccine Adjuvants Based On Novel Amphiphilic Polyanhydrides
Maria P. Torres, Jennifer Wilson, Michael Wannemuehler, Surya K. Mallapragada, Balaji Narasimhan
8:55 AMAnti-HIV Rnai Targeting A Highly Conserved Viral Sequence Results In Novel Mechanisms Of Escape
Priya S. Shah, Joshua N. Leonard, David V. Schaffer
9:20 AMQuantitative Characterization Of Defective Interfering Virus-Like Particles
Kristen Thompson, John Yin
9:45 AMTargeted Gene Therapy of B-Cell Lymphoma by Engineered Retroviral Vectors
Haiguang Yang, Leslie Bailey, Yuning Lei, Taehoon Cho, Kye Il Joo, Bingbing Dai, Lili Yang, Pin Wang
10:10 AMImpact Of Target Mrna Structure On Sirna Silencing Efficiency And Immune Stimulation In RNA Interference
Joseph A. Gredell, Angela Berger, S. Patrick Walton
10:35 AMIn Vitro Studies Of Selective Targeting Of Pigmented Retinal Pigment Epithelial (Rpe) Cells And Subsequent Bio-Stimulation
Qing Song, Ramon Risco Delgado, Mark Latina, Francosi Berthiaume, Yaakov Nahmias, Martin Yarmush

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