Tuesday, November 6, 2007: 8:30 AM-11:00 AM
Room 250 C (Salt Palace Convention Center)

Bioengineering (15c)

#147 - Advances in Cell Culture (15C00)
As the number and quantity of recombinant proteins in development and commercial production has increased over the last few years, the demand on process development and manufacturing facilities has increased as well. While some of this demand can be met by building new infrastructures and facilities, a more efficient and less costly means of meeting these needs is by designing higher productivity processes that are well characterized and robust. This session will focus on recent developments in the field of cell culture process development and engineering with emphasis on enhancing yield and improving robustness of the culture process (i.e., excluding cell line manipulations). Topics include, but are not limited to, advances in bioprocess optimization, bioreactor design and operation, control schemes, scale up/scale down methods, and process analytical techniques for cell culture.
Chair:Sarah W. Harcum
CoChair:M. Nazmul Karim
CoSponsor(s):Pharmaceuticals (15b)
8:30 AMArrayed Bioreactor System For Screening And Optimizing Process Parameters For Recombinant Protein Production In Mammalian Cell Culture
Muhammad A.S. Chaudhry, Mario Jardon, Do Yun Kim, James M. Piret
8:55 AMA Self-Feeding Roller Bottle For Continuous Cell Culture
R. Eric Berson, Goetz Friederichs
9:20 AMImpact Of Impeller Design On Antibody Production By Chinese Hamster Ovary Cells
Sandeepa Sandadi, Patricia Rose, John Bowers, Dennis Rendeiro
9:45 AMModeling Of Individualistic Mammalian Cell Behavior Towards Environmental And Physiological Changes Using Population Balances
Srinivas Karra, M. Nazmul Karim
10:10 AMHigh Throughput Cell Culture Process Optimization By Using Green Fluorescence Protein (Gfp) To Simultaneously Monitor Cell Growth And Protein Production In Microbioreactor Array And Perfusion Bioreactor
Xudong Zhang, Shang-Tian Yang
10:35 AMCharacterization Of The C8161 Melanoma Cell Line For Use In A Tissue Based Bioreactor System
Gregory Rutkowski

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