Tailored peptides have found diverse uses. Long peptides consisting of tens or hundreds of residues (often as diblocks) have been used for the fabrication of hydrogels for tissue scaffolds or drug delivery. Shorter peptides consisting of a few residues (often a few different amino acids in a particular sequence) have been used for the fundamental studies of the formation of peptide aggregates related to disease (amyloid deposits). A common denominator between the two classes of peptides is the presence of either intramolecular secondary structure (hydrogels) or intermolecular secondary structure (amyloid mimics). We have synthesized a series of peptides with unique solution properties. They are short diblock peptides (less than 20 residues long) having either two ionic blocks or one ionic and one hydrophobic block. They are soluble in water and stable under various pH and solvent conditions. Only under very special solvent conditions, they exhibit some secondary structure. Depending of the length and chemistry of each block, they form a distinct aggregate phase upon exposure to a nano-surface (either nano particles or proteins); this aggregation is reversible (depending on the chemistry of the surface) and pH-dependent. The morphology of the aggregate phase has not been determined; but it resembles a composite hydrogel. Potential uses of these peptides are as drug delivery systems and as protein precipitation agents. The use of this family of peptides for the simultaneous isolation of a protein and subsequent delivery in the same matrix is particularly attractive. The aggregates observed so far are very stable at acidic pHs (the pH of the stomach may be as low as 1 when empty or as high as 3 or 4 when food is present). Therefore, the preparation should be able to reach the upper small intestine where the increase in pH will deliver the protein to the blood stream. Although both the selective precipitation of a protein from a mixture and the capability of delivering a protein-based drug orally are important by themselves, we believe that the strongest potential of our discovery is on the simultaneous isolation and delivery of protein products. This conclusion is based on the fact that current methods available for protein purification are highly developed and on the current development of drug delivery methods that individually represent tough competition for our system. Our unique approach (simultaneous isolation and formulation) will definitely find a niche because it will be economically competitive by decreasing the total processing steps with the consequent increase in yield and decrease in cost.