Wednesday, November 7, 2007
516r

Compliance Corrections For The Four-State Actomyosin Model Of Muscle Contraction

Richard L. Long, New Mexico State University, Chemical Engineering Department, P.O. Box 30001, MSC 3805, Las Cruces, NM 88003-8001

Long and Phoonsiri (2006) presented a model of muscle action that both closed the biochemical cycle and employed discreet strain states for the conversion of chemical free energy to mechanical potential energy and then to mechanical kinetic energy. This model was used to compute the force-velocity relation and other responses with a single adjustable parameter which was interpreted as the ratio of two kinetic rate constants. The computed responses were at the macro scale while the model was at the nanoscale. In spite of the fact that the large compliance strains in actin filaments in particular were neglected the results were remarkably well matched to macroscale experimental data. While compliance was not quantitatively considered in Long (1973), it was implicitely allowed through the so-called "strain-locking" conditions in that work. It is thus important to consider how the observed compliance of filaments will affect the results. The results are illustrated here.