Marcos Llusa1, Fernando Muzzio1, and Bodhisattwa Chaudhuri2. (1) Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854, (2) Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06269
The effect of shear rate and strain in the compaction (density increase by 15-10%) of lubricated formulations is studied using a shear cell and computational methods. The Couette shear cell provides uniform shear exposure and specific shear rates. However, as the shear cell operates, the lubricant homogeneity increases, modifying the cohesion of the blend. The latter is assessed using the gravitation displacement rheometer (GDR). This concurrent change on cohesion affects density and the flowability of the blend and the tablet hardness. The experiments show that density increases as a function of strain in two stages, a first steep linear increase and a second almost imperceptible linear increase. However, changes in density are always independent of shear rate. The effect of shear rates and strain for this cell is also studied using discrete element methods (DEM). This method allows avoiding the concurrent changes in cohesion. The coordination number (one of the numerical equivalents for the blend density) is determined for a variety of situations. DEM allows investigating the effect of pins on the walls, speed of the walls, and particle cohesion.