Wednesday, November 15, 2006: 12:30 PM-3:00 PM
Continental 7 (Hilton San Francisco)
#410 - Separations in Biopharmaceutical Downstream Processing I (T2013)
The focus of this session will be the downstream separation processes such as MF/UF, chromatography (ion exchange, reverse phase, size exclusion, affinity), crystallization, etc.
Chair:Kathleen Mihlbachler
CoChair:Todd Menkhaus
12:30 PMComparison of a New Continuous Chromatographic Solvent Gradient Process for Bioseparations with Conventional Processes
Guido Stroehlein, Lars Aumann, Abhijit Tarafder, Thomas Mueller-Spaeth, Massimo Morbidelli
12:50 PMScale down Model Demonstrates High Prodcut Throughputs with Disposable Anion Exchange Chromatography
Jeff D. Mora, Uwe Gottschalk, Oscar Reif, Joe Zhou, Felix Solamo, Shinta Dermawan, Tony Hong, Tim Tressel
1:10 PMDownstream Separation and Scale-up Challenges for E.Coli-Derived Biopharmaceuticals an Industrial Study on Development of an Antibody Fragment (Fab) Process
Abdul Wajid, Daljit Narindray
1:30 PMA Toolbox for Efficient Release and Recovery of Therapeutic Proteins from the Periplasm of Pseudomonas Fluorescens
Anant Patkar, Subrata Sen, Mike Chappell, Yuk Chun Chiu, Jeff Allen, Jefry Shields
1:50 PMDiverse Transgenic Plant Hosts Challenge Downstream Process Development
Zivko L. Nikolov, Susan L. Woodard, Lisa R. Wilken, Steve G. White, Georgia Barros
2:10 PMHigh Throughput Protein Purification Using Negative Mode Hydrophobic Interaction Chromatography
Jennifer McNay, Kenneth Audo, Kevin Bailey
2:30 PMSeparation of Pharmaceutical Process-Related Impurities by an Organic Solvent Nanofiltration Membrane Cascade
Justin Chun-Te Lin, Ludmila G. Peeva, Andrew G. Livingston

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