Friday, November 17, 2006: 12:30 PM-3:00 PM
Yosemite B (Hilton San Francisco)
#661 - Control of polymorphism of APIs or broader value-added materials (T2001)
Different polymorphs of the same chemical entity display distinct physical properties, such as melting point, solubility, dissolution rate, hygroscopicity, stability, etc. The ability to successfully produce and reproduce specific polymorphic modifications is intricately correlated with the efficiency and speed of materials development, the robustness of manufacturing process, and – ultimately – the stability and quality of the targeted value-added materials. Papers are invited on all aspects of the control of polymorphism and pseudopolymorphism, applicable to pharmaceutical development or manufacture of other value-added materials.
Chair:Peter Karpinski
CoChair:Sridhar Desikan
12:30 PMIntroductory Remarks
12:35 PMEffective Evaluation of Solid-Phase Free Energies
Nancy Cribbin, Andrew J. Schultz, Kenneth M. Benjamin, David A. Kofke
12:55 PMImpact of Phase Split Ratio on Agglomeration Behavior in an Api Crystallization
Shekhar K. Viswanath, Ahmad Sheikh, John Tolle, Agnes Pal, James Marek
1:20 PMInvestigation on Polymorphic Transformations of Api Using Raman Spectroscopy
Lili Feng, Zhaoxia Liu, Peter Karpinski
1:45 PMThe Kinetics of L-Glutamic Acid Precipitation: Characterization and Modeling
Marco Mazzotti, Lars Vicum, Christian Lindenberg, Jochen Schöll, Jörg Brozio
2:10 PMPolymorphism in the Crystallization of Glycine
Xia Yang, Chi Bun Ching, Xiu Juan Wang, Jie Lu
2:35 PMDirect Growth of Gamma Glycine from Neutral Aqueous Solutions by Slow, Evaporation-Driven Evaporation
Paul J. A. Kenis, Guangwen He, Venkateswarlu Bhamidi, Scott R. Wilson, Reginald B. H. Tan, Charles F. Zukoski
2:55 PMConcluding Remarks

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