Monday, November 13, 2006: 8:30 AM-11:00 AM | |||
Union Square 1 & 2 (Hilton San Francisco) | |||
#24 - Fundamentals of Protein Degradation and Stabilization (01A06) | |||
Protein degradation occurs throughout the life cycle of biotechnology products, and can involve a variety of physical and chemical routes. This session seeks contributions that focus at a fundamental level on the mechanism(s), kinetics, and/or quantitative modeling of one or more degradation pathways for proteins in vitro or in vivo. These may include, but are not limited to: deamidation, oxidation, proteolysis, and non-native aggregation. Priority will be given to those contributions that provide insights or applications of general use, and those that apply modern computational or theoretical tools. | |||
Chair: | Christopher J. Roberts | ||
CoChair: | Bernhardt L. Trout | ||
8:30 AM | 24a | Self-Assembly, Phase Separation, and Unfolding of Coarse-Grained Proteins in Solution Jason K. Cheung, Vincent K. Shen, Jeffrey R. Errington, Thomas M. Truskett | |
8:55 AM | 24b | Computer Simulation of Fibril Forming Peptides with an Intermediate Resolution Protein Model Victoria Wagoner, Carol K. Hall | |
9:20 AM | 24c | Computing Free Energies of Peptide-Mediated Protein-Protein Interactions in Modeling Immune System Response Jindal K. Shah, Dilip Asthagiri, Michael E. Paulaitis | |
9:45 AM | 24d | Impact of Ion Hydration and Preferential Interactions on Salt-Induced Protein Deactivation Kinetics James M. Broering, Andreas S. Bommarius | |
10:10 AM | 24e | Thermodynamics, Structure, and Oligomerization States of Key Intermediates in Non-Native Chymotrypsinogen Aggregate Initiation and Growth Jennifer Andrews, Christopher J. Roberts | |
10:35 AM | 24f | Structural Studies of the Self-Assembly and Stability of Viral Capsids Hung D. Nguyen, Charles L. Brooks III |
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