- 2:10 PM

Is It Del B, or Del B^2? That Is the Question

Jeffrey J. Chalmers1, Maciej Zborowski2, Jianxin Sun1, and Yang Zhao1. (1) Chemical and Biomolecular Engineering, The Ohio State University, 125 Koffolt Labs, 140 W. 19th Ave., Columbus, OH 43210, (2) Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH

The Zborowski and Chalmers lab have been advocating the use of magnetophoretic mobility as a means to both characterize the degree to which a cell is immunomagnetic labeled as well as a means to design, operate, and analyze the performance of immunmagnetic cell separation systems. A common criticism/concern of our method of calculating magnetophoretic mobility is the use of the magnetic energy gradient calculated as Del B^2 instead of Del B.

In this presentation we will present our experimental studies with our modified electromagnetic CTV system which allows us to vary the value of B over and order of magnitude. This allows for the direct answering of the question: Is the magnetophoretic mobility constant as Del B^2 changes? We will present experimental evidence that based on the material and value of B, both sides in the debate are correct.