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Copper Chloride - Assisted Oxidative Cyclization of Amidrazones Derivatives

Raid J. Abdel-Jalil1, Al-Nuaimi Musa1, and Samer I. Al-Gharabli2. (1) Chemistry Department, Hashemite University, Zarka, Jordan, (2) Chemical-Pharmaceutical Engineering Department, German-Jordanian University, Amman, Jordan

Several compounds containing amidrazone moiety are known to have interesting biological activities as anticancer, anti-inflammatory, and potent inhibitors of lipoxygenase-1. Herein we present a facile method for the regioselective synthesis of benzotriazines based on catalytic cyclization. Endowed oxidative ring closure of arylamidrazone containing compounds achieved after short treatment with CuCl2 solution. As a proof of principle, several derivatives of benzotriazines were synthesized and characterized with good purity and selectivity. Biological activity tests towards lung cancer are ongoing.