- 12:30 PM

Think out of the Box - a Case Study of a Photosensitivity Phenomenon during Mab Product Recovery

Xiaoyang Zhao, PD, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320

Primary Recovery is a key step to link cell culture and purification. In monoclonal antibody production, a typical recovery process includes centrifugation, filtration and capture chromatography. Most recovery optimization is focused on improving the process yield and reducing its cost.

A case study is presented here of a photosensitivity phenomenon with potential impact to product stability. The main contributing factors that caused the photosensitivity were identified and process conditions developed to minimize these effects.