451am

An Age-Structured Model of Dendritic Cell Trafficking in the Lung

David Klinke, Department of Chemical Engineering, West Virginia University, P.O. Box 6102, Morgantown, WV 26506-6102

As the sentinels of the immune system, dendritic cells (DC) play a critical role in initiating and maintaining appropriate T cell responses through capture and presentation of antigen, costimulation, and mediator release. From an engineering perspective, DC also exhibit multi-scale characteristics as their actions span multiple spatial compartments and vary temporally. Although much is known about certain aspects of DC function, the exact relationship between lung epithelial DC precursor populations in the blood and their functional role in antigen presentation is not clearly understood. An age-structured mathematical model for DC trafficking into the lung was created to address this question. While capturing experimentally observed system dynamics, I found that blood DC are preferentially recruited over blood monocytes. For short-lived antigens, the model results suggest that lung epithelial DC derived from blood DC exhibit a 625% increase in antigen density compared to those derived from blood monocytes. Finally, these results motivate future experimental studies to clarify aspects of DC trafficking in the lung.